Neural regeneration in Caenorhabditis elegans.

نویسندگان

  • Rachid El Bejjani
  • Marc Hammarlund
چکیده

Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans.

The nematode Caenorhabditis elegans is a widely adopted model organism for studying various neurobiological processes at the molecular and cellular level in vivo. With a small, flexible, and continuously moving body, the manipulation of C. elegans becomes a challenging task. In this review, we highlight recent advances in microfluidic technologies for the manipulation of C. elegans. These new f...

متن کامل

استفاده از تعامل نماتد Caenorhabditis elegans، قارچ Arthrobotrys oligospora و باکتری Bacillus subtilis در کنترل نماتد Meloidogyne javanica

در این تحقیق از تعامل نماتد Caenorhabditis elegans، قارچ Arthrobotrys oligospora و باکتری Bacillus subtilis در کنترل نماتد مولد گره ریشه Meloidogyne javanica استفاده شد. باکتری مذکور جهت تحریک سیستم دفاعی گیاه در بدو تیمار و به عنوان غذای نماتد C. elegans و نماتد C. elegans به منظور افزایش تولید تله استفاده شد. قارچoligospora A. پس از 72 ساعتموجب مرگ و میر 77% لاروهای نماتد M. javanica ‌گردید، ...

متن کامل

Enhancement of neuronal regeneration by optogenetic cellular activation in C. elegans

Large numbers of people suffer from nervous system injuries and neurodegenerative diseases each year, with little success in regaining lost neural functions. Attempts to successfully regenerate nervous tissue in the mammalian Central Nervous System have meet with limited success. Simpler models have thus been useful in determining conserved mechanisms in the enhancement of neural regeneration. ...

متن کامل

MAP kinase cascades regulating axon regeneration in C. elegans

Mitogen-activated protein kinase (MAPK) signaling cascades are activated by diverse stimuli such as growth factors, cytokines, neurotransmitters and various types of cellular stress. Our evolving understanding of these signal cascades has been facilitated by genetic analyses and physiological characterization in model organisms such as the nematode Caenorhabditis elegans. Genetic and biochemica...

متن کامل

Determination of the effects of food preservatives benzoic acid and sodium nitrate on lifespan, fertility and physical growth in Caenorhabditis elegans

Presently, the use of protective food additives such as benzoic acid and sodium nitrate is quite common. However, it was found that these additives, which initially appeared to be harmless, led to the emergence of a number of health problems. Cancer and diseases and deaths with no apparent causes are among the leading concerns. Therefore, the studies which can reveal the genotoxic potential of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Annual review of genetics

دوره 46  شماره 

صفحات  -

تاریخ انتشار 2012